Clinical Lab Handbook

Container/Tube: Lavender-top (EDTA) tube

Specimen Volume: 500μL whole blood

The iSED® analyzer uses quantitative capillary photometry (aggregation) to measure erythrocyte sedimentation rate (ESR) faster than most traditional methods by capturing the kinetics of Red Blood Cell aggregation in a controlled testing environment during the most critical phase of sedimentation, commonly referred to as the lag or Rouleaux formation phase.

The ESR is helpful in revealing inflammatory activity and in monitoring the progress of conditions associated with acute and chronic inflammation, including infections, cancers, and autoimmune diseases.

The ESR is particularly useful in evaluating patients with unexplained symptoms, when infectious diseases are suspected and when a specific diagnosis is not available effectively using other tests.

The ESR provides particularly valuable information in conditions such as temporal arteritis, polymyalgia rheumatica, giant cells arteritis, inflammatory arthropaties, etc.

Limitations: Sickle cell anemia and multiple myeloma are two conditions that are incompatible with an accurate ESR result when using both the Westergren method and ALCOR analyzers. ESR is increased in cases of multiple myeloma but is not related to an inflammatory condition.

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