Clinical Lab Handbook

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The LIAISON® HSV-1 and HSV-2 Type Specific IgG assay is a chemiluminescent immunoassay (CLIA) to be used with the LIAISON® Analyzer for the qualitative determination of type specific IgG antibodies to Herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) in human serum. The assay is indicated for testing sexually active adults or expectant mothers to aid in the presumptive diagnosis of HSV-1 and HSV-2 infections.

Herpes simplex virus (HSV) is an enveloped, DNA-containing virus morphologically similar to the other members of the Herpetoviridae family. Two naturally occurring variants of HSV, with different biologic and epidemiologic characteristics, are recognized by restriction-endonuclease or antigenic analysis. Both types of virus cause infections in humans which range in severity from cold sores to encephalitis. Once infection occurs, HSV persists in a latent state in sensory ganglia from where it may re-emerge to cause periodic recurrence of infection induced by many stimuli, which may or may not result in clinical lesions. Immunocompromised patients are more likely to have frequent HSV recurrences.

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